A truncation mutant of adenomatous polyposis coli (APC) impairs apical cell extrusion through elevated epithelial tissue tension
W. J. Gan, R. Giri, J. Begun, H. Abud, E. C. Hardeman, P. W. Gunning, A. S. Yap, I. Noordstra
This study shows that an APC truncation mutant increases epithelial tissue tension via RhoA/ROCK, impairing apical cell extrusion and potentially contributing to disease.
bioRxiv · Mar 6, 2024Cell Biology