Mimicking Kidney Flow Shear Efficiently Induces Aggregation of LECT2, a Protein Involved in Renal Amyloidosis
J.-H. Ha, Y. Xu, H. Sekhon, S. Wilkens, D. Ren, S. N. Loh
This study shows that kidney-like flow shear in microfluidic devices efficiently induces LECT2 aggregation, with the I40V mutation enhancing fibril formation and aggregate size.
bioRxiv · Jul 13, 2023Biochemistry