Perturbation of ubiquitin homeostasis promotes macrophage oxidative defenses
M.-E. Charbonneau, K. Passalacqua, S. Hagen, H. Showalter, C. Wobus, M. O'Riordan
This study shows that disrupting ubiquitin homeostasis in macrophages increases reactive oxygen species production, enhancing anti-infective capacity through NOX2 and calcium signaling.
bioRxiv · Mar 5, 2018Immunology