Author

C. Wobus

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Evolutionary Biology· 1 Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Research Focus:host-pathogen & immune response· 3 Approach:experimental assay· 2 Approach:biophysical modeling· 1 Organism:mouse· 1

Frequent Co-Authors

A. Feldman· 1 shared A. Fischer· 1 shared A. Kolawole· 1 shared A. O. Kolawole· 1 shared A. Rotem· 1 shared A. Serohijos· 1 shared C. Chang· 1 shared C. Wilen· 1 shared

Activity by Year

2016-2020 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperEvolutionary Biology

A. Feldman

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3 papers

Recent·Most cited

CD300lf is the primary physiologic receptor of murine norovirus but not human norovirus

V. Graziano, F. C. Walker, E. A. Kennedy, J. Wei, K. Ettayebi, M. Simoes, R. Filler, E. Hassan, L. L. Hsieh, A. O. Kolawole, C. Wobus, L. C. Lindesmith, R. S. Baric, M. Estes, R. C. Orchard, , C. Wilen

This paper identifies CD300lf as the primary receptor for murine norovirus in vivo but shows it is not used by human norovirus.

PLOS Pathogens · Apr 6, 2020Peer-reviewedMicrobiology

Perturbation of ubiquitin homeostasis promotes macrophage oxidative defenses

M.-E. Charbonneau, K. Passalacqua, S. Hagen, H. Showalter, C. Wobus, M. O'Riordan

This study shows that disrupting ubiquitin homeostasis in macrophages increases reactive oxygen species production, enhancing anti-infective capacity through NOX2 and calcium signaling.

bioRxiv · Mar 5, 2018Immunology

Tuning the course of evolution on the biophysical fitness landscape of an RNA virus

A. Rotem, A. Serohijos, C. Chang, J. Wolfe, A. Fischer, T. Mehoke, H. Zhang, Y. Tao, L. Ung, J.-M. Choi, A. Kolawole, S. Koehler, S. Wu, P. Thielen, N. Cui, , E. Shakhnovich

This study predicts the evolutionary pathway of norovirus escaping antibodies using a biophysical fitness model, validated by experimental evolution in bulk culture and microfluidics.

bioRxiv · Dec 8, 2016Evolutionary Biology