Dissecting the cell of origin of aberrant SALL4 expression in myelodysplastic syndrome
H. Tatetsu, M. Watanabe, J. Liu, K. Tokunaga, E. Iwanaga, Y. Komohara, E. Thrash, M. Matsuoka, D. G. Tenen, L. Chai
This study identifies the cellular origin of aberrant SALL4 expression in MDS using mass cytometry, showing it is mainly in HSPC and myeloid lineages, with SALL4/p53 co-expression linked to TP53 mutations.
bioRxiv · Dec 5, 2022Cell Biology