Crystallization and structure of ebselen bound to cysteine 141 of human inositol monophosphatase (IMPase).
G. D. Fenn, H. Waller-Evans, J. R. Atack, B. D. Bax
The paper presents the 1.47 Å crystal structure of human IMPase bound to ebselen, showing covalent attachment to Cys141 and tetramer formation through dimer interactions.
bioRxiv · Jul 8, 2020 · PreprintPharmacology & Toxicology