Author

Hadley Osman

Buck Institute for Research on Aging

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genetics· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Organism:C. elegans· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Assay:metabolomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Anna FoulgeriD· 2 shared Gordon J. LithgowiD· 2 shared Angelina HolcomiD· 1 shared Anna L Coleman-HulbertiD· 1 shared Birgit SchillingiD· 1 shared Brian OnkeniD· 1 shared Christina D. KingiD· 1 shared Christine A. SedoreiD· 1 shared

Activity by Year

2023-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersGenetics

Anna FoulgerORCID

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Author profile →

2 papers

Recent·Most cited

Computer prediction and genetic analysis identifies retinoic acid modulation as a driver of conserved longevity pathways in genetically-diverse Caenorhabditis nematodes

Stephen A. Banse, Christine A. Sedore, Anna L Coleman-Hulbert, Erik Johnson, Brian Onken, David Hall, Erik Segerdell, E Grace Jones, Yuhua Song, Hadley Osman, Jian Xue, Elena Battistoni, Suzhen Guo, Anna Foulger, Madhuri Achanta, , Patrick C. Phillips

The paper identifies retinoic acid modulation as a driver of longevity pathways in C. elegans using computational predictions and genetic analysis of 16 compounds.

eLife · Dec 23, 2025Peer-reviewedGenetics

Neuronal expression of human amyloid-β and Tau drives global phenotypic and multi-omic changes in C. elegans

Angelina Holcom, Matías Fuentealba, Renuka Sivapatham, Christina D. King, Hadley Osman, Anna Foulger, Dipa Bhaumik, Birgit Schilling, David Furman, Julie Kay Andersen, Gordon J. Lithgow

This study shows that expressing human amyloid-β and Tau in C. elegans neurons causes phenotypic and multi-omic changes, including accelerated aging and metabolic dysfunction.

bioRxiv · Jun 1, 2023 · PreprintSystems Biology