Geranylgeranylated-SCFFBXO10 Regulates Selective Outer Mitochondrial Membrane Proteostasis and Function
Sameer Ahmed Bhat, Zahra Vasi, Liping Jiang, Shruthi Selvaraj, Rachel Ferguson, Anish Gudur, Hagar Ismail, Ritika Adhikari, Avantika Dhabaria, Beatrix Ueberheide, Shafi Kuchay
This study identifies how geranylgeranylation of FBXO10 enables its targeting to the outer mitochondrial membrane, where it regulates PGAM5 ubiquitination and mitochondrial function.
bioRxiv · Apr 16, 2024 · PreprintCell Biology