Author

Hakwoo Lee

BC Cancer Agency

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioinformatics· 1 Cancer Biology· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:statistical model· 3 Research Focus:clustering· 2 Research Focus:differential expression· 2 Approach:benchmark study· 1 Research Focus:benchmarking· 1 Research Focus:cell type annotation· 1 Research Focus:deconvolution· 1

Frequent Co-Authors

Andrew J. L. RothiD· 3 shared Ciara H. O’FlanaganiD· 3 shared Daniel LaiiD· 3 shared Samuel A. J. R. AparicioiD· 3 shared Sean BeattyiD· 3 shared Elena ZaikovaiD· 2 shared Eric LeeiD· 2 shared Esther KongiD· 2 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersBioinformatics

Andrew J. L. RothORCID

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Author profile →

3 papers

Recent·Most cited

Serval: A modular framework for decoding imaging based spatial transcriptomics data

Jenkin Tsui, Naila Adam, Woongcheol Choi, Luna Y Liu, C. Cárcamo Flores, Shadi Ansari, Esther Kong, Yukta Thapliyal, Hakwoo Lee, Shahid Haider, Issac Von Riedemann, Ciara H. O’Flanagan, Mohammad Al Sa’d, Bruno Albuquerque, Hamid Raza Ali, , Nicholas A. Walton

Serval is a modular framework for decoding spatial transcriptomics data that introduces Cosine, a method improving transcript recovery and correlation with expression references.

Bioinformatics · Sep 27, 2026Peer-reviewedBioinformatics

Somatic copy number mutations contribute to fitness in transplantation models of spontaneous human breast cancer metastasis

Hoa Tran, Gurdeep Singh, Hakwoo Lee, Damian Yap, Eric Lee, William Daniels, Farhia Kabeer, Ciara H. O’Flanagan, Vinci Au, Michael Van Vliet, Daniel Lai, Elena Zaikova, Sean Beatty, Esther Kong, Shuyu Fan, , Samuel A. J. R. Aparicio

This study shows that somatic copy number mutations (CNA) influence metastatic fitness in breast cancer by mediating transcriptional changes and affecting clone survival in different sites.

bioRxiv · Oct 27, 2025 · PreprintCancer Biology

Single cell decoding of drug induced transcriptomic reprogramming in triple negative breast cancers

Farhia Kabeer, Hoa Tran, Mirela Andronescu, Gurdeep Singh, Hakwoo Lee, Sohrab Salehi, Beixi Wang, Justina Biele, Jazmine Brimhall, David Gee, Viviana Cerda, Ciara H. O’Flanagan, Teresa Ruiz de Algara, Takako Kono, Sean Beatty, , Samuel A. J. R. Aparicio

The paper identifies genomic and non-genomic contributions to drug resistance in triple negative breast cancer using single cell transcriptomics and copy number data.

Genome biology · Jul 18, 2024Peer-reviewedGenomics