Dominant Malignant Clones Leverage Lineage Restricted Epigenomic Programs to Drive Ependymoma Development
Alisha Kardian, Hua Sun, Siri Manasa Ippagunta, Nic Laboe, Srinidhi Varadharajan, Kwanha Yu, Hsiao‐Chi Chen, Erik Emanus, Tuyu Zheng, Riley M. Deneen, Jon P. Connelly, Yong-Dong Wang, Jiangshan Zhan, Hengxi Liu, Kimberley Lowe, , Stephen C. Mack
This study identifies specific developmental epigenomic states that enable ZFTA-RELA-driven ependymoma formation and reveals how these states shape tumor progression.
Nature · Mar 25, 2026Peer-reviewedCancer Biology