A genome-wide CRISPR screen reveals cancer-specific regulators of hyaluronan binding and cellular invasion
Jimmy Kim, Halen Kovacs, Anjali Parthasarathy, Shini Chen, Vignesh Krishnamoorthy, Mohammed Al‐Seragi, May Zhao, Yu‐Hsuan Huang, Pamela Austin Dean, Pauline Johnson, Calvin D. Roskelley, Simon Wisnovsky
This study uses a CRISPR screen to identify genes regulating CD44-HA binding in breast cancer, revealing RAB4A as a novel regulator of invasion and potential therapeutic target.
bioRxiv · Feb 9, 2026 · PreprintCancer Biology