High-fat diet rewires gut host-microbiota relationship to derive worse outcomes following Clostridioides difficile infection
Archit Kumar, N. M. Nguyen, Martin O’Brien, Kimberly C. Vendrov, Alexandra K. Standke, Hannah Ruppel, Ivy Earl, Ingrid L. Bergin, Vincent Bensan Young, Raymond L. Yung
This study shows high-fat diets worsen outcomes of Clostridioides difficile infection in mice by altering immune responses and gut microbiota.
bioRxiv · Jan 5, 2026 · PreprintMicrobiology