Murine metabolic HFpEF is associated with mitochondrial substrate inflexibility and S-nitrosylation remodeling
Sofia‐Iris Bibli, Hanyu Cui, Daiyu Wang, Florian Leuschner, Joerg Heineke, Jiong Hu
This study identifies mitochondrial metabolic inflexibility and S-nitrosylation remodeling in a murine HFpEF model and shows ketone supplementation partially rescues metabolic and functional defects.
bioRxiv · Jul 13, 2026 · PreprintBiochemistry