Author

Hariharan Jayashankar

National Bureau of Economic Research

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genetic & Genomic Medicine· 1 Genetics· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 3 Assay:GWAS summary statistics· 2 Organism:human· 2 Approach:Bayesian inference· 1 Research Focus:benchmarking· 1 Research Focus:database / resource· 1 Research Focus:GWAS / association mapping· 1 Research Focus:imputation· 1

Frequent Co-Authors

Alexander I. YoungiD· 3 shared Aysu OkbayiD· 3 shared Daniel Jacob BenjaminiD· 3 shared David A. CesariniiD· 3 shared Patrick TurleyiD· 3 shared Augustine KongiD· 2 shared Elliot M. Tucker–DrobiD· 2 shared Matt K. McGueiD· 2 shared

Activity by Year

2021-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersGenetic & Genomic Medicine

Alexander I. YoungORCID

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3 papers

Recent·Most cited

Family-GWAS reveals effects of environment and mating on genetic associations

Tammy Tan, Hariharan Jayashankar, Junming Guan, Seyed Moeen Nehzati, Mahdi Mir, Michael Bennett, Esben Agerbo, Rafael Ahlskog, Ville Anapaz, Stefania Benónísdóttir, Dorret Irene Boomsma, Archie I Campbell, Christopher F. Chabris, Zhengming Chen, China Kadoorie Biobank Collaborative Group, , Alexander I. Young

Family-based GWAS meta-analysis of 34 phenotypes shows standard GWAS effects carry sizeable confounding uncorrelated with direct genetic effects, while assortative mating likely inflates SNP heritability and genetic correlations.

medRxiv · Oct 1, 2024 · PreprintGenetic & Genomic Medicine✦ In-depth digest

Mendelian imputation of parental genotypes for genome-wide estimation of direct and indirect genetic effects

Alexander I. Young, Seyed Moeen Nehzati, Stefania Benónísdóttir, Aysu Okbay, Hariharan Jayashankar, Chan Wook Lee, David A. Cesarini, Daniel Jacob Benjamin, Patrick Turley, Augustine Kong

The paper develops a method to impute parental genotypes from sibling data to estimate direct and indirect genetic effects, finding that standard GWAS underestimates direct effects for several traits.

Nature Genetics · Jun 1, 2022Peer-reviewedGenetics

Resource Profile and User Guide of the Polygenic Index Repository

Joël Becker, Casper A.P. Burik, Grant Goldman, Nancy Wang, Hariharan Jayashankar, Michael Bennett, Daniel W. Belsky, Richard Karlsson Linnér, Rafael Ahlskog, Aaron Kleinman, David A. Hinds, Michelle Agee, Babak Alipanahi, Adam Auton, Robert K. Bell, , Aysu Okbay

The paper constructs polygenic indexes for 47 phenotypes across 11 datasets and provides a tool to correct errors-in-variables bias when using PGIs as proxies for the additive SNP factor.

Nature Human Behaviour · Jun 17, 2021Peer-reviewedGenomics