Author

Harold Wang

Broad Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genomics· 3

Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:statistical model· 3 Research Focus:variant calling· 3 Assay:whole-genome sequencing· 3 Approach:benchmark study· 1 Research Focus:benchmarking· 1 Research Focus:database / resource· 1 Approach:experimental assay· 1

Frequent Co-Authors

Harrison BrandiD· 3 shared Xuefang ZhaoiD· 3 shared Ben WeisburdiD· 2 shared Chelsea LowtheriD· 2 shared Jack M. FuiD· 2 shared Mark WalkeriD· 2 shared Michael E. TalkowskiiD· 2 shared Ryan L. CollinsiD· 2 shared

Activity by Year

2020-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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3 shared papersGenomics

Harrison BrandORCID

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Author profile →

3 papers

Recent·Most cited

De novo structural mutation rates and gamete-of-origin biases revealed through genome sequencing of 2,396 families

Jonathan R. Belyeu, Harrison Brand, Harold Wang, Xuefang Zhao, Brent S. Pedersen, Julie Ellen Feusier, Meenal Gupta, Thomas J. Nicholas, Joseph Brown, Lisa Morrison Baird, Bernie Devlin, Stephan Sanders, Lynn B. Jorde, Michael E. Talkowski, Aaron R. Quinlan

The paper reports de novo structural mutation rates and gamete-of-origin biases using genome sequencing of 2,396 families, finding higher rates in autism cases and paternal origin dominance.

The American Journal of Human Genetics · Mar 6, 2021Peer-reviewedGenomics

Expectations and blind spots for structural variation detection from short-read alignment and long-read assembly

Xuefang Zhao, Ryan L. Collins, Wan-Ping Lee, Alexandra M. Weber, Yukyung Jun, Qihui Zhu, Ben Weisburd, Yongqing Huang, Peter A. Audano, Harold Wang, Mark Walker, Chelsea Lowther, Jack M. Fu, Mark Gerstein, Scott E. Devine, , Michael E. Talkowski

The paper compares structural variant detection using short-read and long-read sequencing in three trios, showing lrWGS finds more SVs but srWGS has high concordance in non-repetitive regions.

bioRxiv · Jul 3, 2020 · PreprintGenomics

An open resource of structural variation for medical and population genetics

Ryan L. Collins, Harrison Brand, Konrad J. Karczewski, Xuefang Zhao, Jessica Alföldi, Laurent C. Francioli, Amit V. Khera, Chelsea Lowther, Laura Doyle Gauthier, Harold Wang, Nicholas A. Watts, Matthew Solomonson, Anne O’Donnell‐Luria, Alexander Baumann, Ruchi Munshi, , Adolfo Correa

Short-read genome sequencing of 14,891 diverse genomes yields 433,371 structural variants (SVs) for gnomAD; loss-constrained genes also resist duplication, and clinical SV carrier rates are benchmarked.

Nature · May 27, 2020Peer-reviewedGenomics✦ In-depth digest