FcγR- and CD9-dependent synapse engulfing microglia in the thalamus drive cognitive impairment following cortical brain damage
Ken Matoba, Takahiro Kochi, Oluwaseun Fatoba, Md Sorwer Alam Parvez, Inssaf Berkiks, Yassin Mreyoud, Harrison Strong, Jana H. Badrani, Hency Patel, Yoshiko Nagaoka-Kamata, Masakazu Kamata, Hiroshi Tsujioka, Toshihide Yamashita, David K. Crossman, Minae Niwa, Shin‐ichi Kano
The paper shows that thalamic microglia engulfing synapses, driven by CD9 and FcγRIII signals, cause cognitive impairment after cortical injury.
Nature Communications · Jul 9, 2026Peer-reviewedImmunology