Bronsted-basic small molecules activate GTP hydrolysis in Ras Q61 mutants
Yecheng Wang, Si‐Cong Chen, Yang Wu, Yan Cao, Zhongda Shi, Michael A. Norinskiy, Celine D. Wang, Hasan Celik, Ziyang Zhang
The paper identifies small molecules that enhance GTP hydrolysis in K-Ras Q61 mutants, reducing GTP-bound Ras and downstream signaling.
bioRxiv · Nov 4, 2025 · PreprintCancer Biology