Yang Wu

Estrogen-Deficiency Degrades Left Ventricular Diastolic Function and Energy Metabolism in Hypertensive Female Mice

This study shows that estrogen deficiency worsens diastolic dysfunction and energy metabolism in hypertensive female mice, with improvements seen when estrogen or its receptor agonists are administered.

Modeling Meibomian Gland Development and Dysfunction: A Mouse-Derived Organoid System Reveals Hippo-YAP as a Critical Regulator

This study develops a mouse-derived organoid model of meibomian glands and identifies the Hippo-YAP pathway as critical for gland development and dysfunction.

CNS diseases cerebrospinal fluid single-cell atlas reveals immune characteristics of neuropsychiatric systemic lupus erythematosus

The paper constructs a single-cell atlas of cerebrospinal fluid and blood from CNS diseases, revealing immune features of NPSLE and providing a public resource for future research.

Co-evolution of Oncogenic KRAS Signaling and LILRBhigh Macrophages Drives Pancreatic Cancer Recurrence

This study identifies a co-evolved tumor-immune interaction involving KRAS signaling and LILRBhigh macrophages that drives PDAC recurrence and presents a therapeutic strategy targeting this axis.

Spatial patterns of APOBEC mutagenesis in the tumour microenvironment of Asian breast cancer

This study investigates how APOBEC mutagenesis and A3B deletion affect immune activation in Asian breast cancer using spatial transcriptomics, finding that mitochondrial mutations and cGAS-STING pathway activation drive immune responses instead of neoantigens.

Bronsted-basic small molecules activate GTP hydrolysis in Ras Q61 mutants

The paper identifies small molecules that enhance GTP hydrolysis in K-Ras Q61 mutants, reducing GTP-bound Ras and downstream signaling.

Recurrently deregulated lncRNAs associated with HCC tumorigenesis and metastasis revealed by genomic, epigenomic and transcriptomic profiling in paired primary tumor and PVTT samples

The paper identifies recurrently deregulated lncRNAs in HCC and PVTT samples, linking them to metastasis and prognosis using multi-omics data.