CRISPR-mediated conditional mutagenesis of Smad1/5/8 reveals BMP/GDF signaling restricts postnatal bone overgrowth
Rimma Levina, Alexander J. Weitzel, Alexander Y. Liu, Benjamin E. Low, Pierce W. Ford, Hayley Halaby, Hannah A. Grunwald, Erica G. Gacasan, Yasaman Moharrer, Robert L. Sah, Eric J. Bennett, Joel D. Boerckel, Michael V. Wiles, Kimberly L. Cooper
This paper uses CRISPR-mediated conditional mutagenesis to show BMP/GDF signaling restricts postnatal bone overgrowth by regulating both periosteal and endosteal osteoblasts.
bioRxiv · Jan 23, 2026 · PreprintGenetics