VPS41 deletion triggers progressive loss of insulin stores and downregulation of beta-cell identity
Belinda Yau, Yousun An, Mark Germanos, Patricia Schwarzkopf, A. Gabrielle J. van der Kraan, Mark Larance, Hayley Webster, Christian Shizuo Burns, Cédric S. Asensio, Melkam Alamerew Kebede
This study shows that VPS41 deletion causes insulin degradation and loss of beta-cell identity in mice, with lysosomal inhibition rescuing insulin content.
American Journal of Physiology-Endocrinology and Metabolism · Dec 24, 2024Peer-reviewedCell Biology