HECT-type ligases facilitate autoubiquitination and degradation of other ubiquitin ligases to activate plant immunity
Zhishuo Wang, Robert L Mason, Heather Grey, Christos Spanos, Beatriz Orosa‐Puente, Steven H. Spoel
This study shows that HECT-type ligases UPL3/4 promote the degradation of other E3 ligases like PUB22, thereby regulating immune-related substrate stability and plant immunity.
bioRxiv · Oct 10, 2026 · PreprintPlant Biology