Fully T2T pedigree assemblies reveal genetic stability and epigenetic plasticity of human centromeres across inheritance and cell-fate transitions
Shihua Dong, Xiaoyun Xing, Monika Čechová, Hailey Loucks, Selvamani Vijayalingam, Amber Neilson, Monica F. Sentmanat, Juan F. Macias-Velasco, T -C Liu, Zheng Dong, Benpeng Miao, Wenjin Zhang, Chad Tomlinson, Heather K. Schmidt, Edward A. Belter, , Ting Wang
The paper uses fully phased telomere-to-telomere assemblies and long-read epigenomes to study centromere genetic and epigenetic dynamics across inheritance and cell-fate transitions, finding positional stability of CDRs and dynamic epigenetic changes.
bioRxiv · Feb 17, 2026 · PreprintGenomics