Author

Heather Loughnane

Trinity College Dublin

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Assay:scRNA-seq· 2 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

Darren RuaneiD· 3 shared Patrick T. WalshiD· 3 shared Shrikanth Chomanahalli BasavarajappaiD· 3 shared Séamus HusseyiD· 2 shared Anna Dominik· 1 shared Anne MooreiD· 1 shared Bradford L. McRae· 1 shared Conor M. FinlayiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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3 shared papersImmunology

Darren RuaneORCID

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3 papers

Recent·Most cited

Deficiency of IL-36 receptor antagonist (DITRA) is associated with decreased homoeostatic CCL27 expression leading to heightened dermal inflammation.

Shrikanth Chomanahalli Basavarajappa, Paloma Narros‐Fernández, Heather Loughnane, Larissa Bless, Yasmina Hernandez-Santana, Eirini Giannoudaki, Anne Moore, Margaret B. Lucitt, Darren Ruane, Patrick T. Walsh

This study shows that IL-36Ra deficiency reduces CCL27 expression, leading to skin inflammation in DITRA patients and mice, and that restoring CCL27 mitigates inflammation.

bioRxiv · Jun 12, 2026 · PreprintImmunology

Targeting redox imbalance through Nrf2 activation in the inflamed coeliac duodenum.

Heather Loughnane, Shrikanth Chomanahalli Basavarajappa, Anna Dominik, Conor M. Finlay, Séamus Hussey, Darren Ruane, Patrick T. Walsh

This study uses single-cell transcriptomics to show redox imbalance in coeliac duodenum, with decreased Nrf2 activation in key cell types, and demonstrates that Nrf2 activation reduces inflammation.

Clinical & Experimental Immunology · Jan 1, 2026Peer-reviewedImmunology

Immune signaling mediates stromal changes to support epithelial reprogramming in Celiac duodenum

Dylan Richards, Klebea Sohn, Shrikanth Chomanahalli Basavarajappa, Daniel M. Horowitz, Joshua James Rusbuldt, Lynn Tomsho, Kate Paget, Ivan Chavez, Koen Van den Berge, Bradford L. McRae, Heather Loughnane, Séamus Hussey, Patrick T. Walsh, Darren Ruane

This study identifies immune-stromal-epithelial communication in CeD duodenum using scRNA-seq, revealing fibroblast-mediated epithelial reprogramming through IL-1β and IFN-γ signals.

Cell Reports · Jul 21, 2025Peer-reviewedImmunology