Copper deficiency drives OXPHOS impairment and mitochondrial hyperfusion via MTCH2 in skeletal muscle
Young-Seung Lee, Hee Soo Kim, Phuc L. Nguyen, Junhyeong Lee, Dong‐Il Kim, Jeongmin Lee, Changjong Moon, Kyoung‐Oh Cho, Byung-Eun Kim, Jiyun Ahn, Timothy F. Osborne, Taner Duysak, Jeong‐Sun Kim, Chang Hwa Jung, Tae Il Jeon
This study shows that copper deficiency in skeletal muscle leads to mitochondrial dysfunction and hyperfusion via MTCH2, and restoring copper rescues these defects.
bioRxiv · Nov 19, 2025 · PreprintMolecular Biology