Coordinated IFN-γ/TNF Axis Drives Selective Loss of Activated Enteric Glia in Inflammatory Bowel Diseases
Marvin Bubeck, Klara Penkert, Heidi Limberger, Miguel Gonzalez Acera, Christina Plattner, Svenja Ziegler, Anoohya N. Muppirala, Patrycja M. Forster, Manuel O. Jakob, Reyes Gámez‐Belmonte, Lena Erkert, Subhash Kulkarni, Claudia Günther, Raja Narayana Atreya, Anja A. Kuehl, , Dieter Chichung Lie
This study identifies IBD type-associated EGC activation signatures and reveals TNF/IFN-γ-driven necroptosis of activated enteric glia in inflammatory bowel diseases.
Cellular and Molecular Gastroenterology and Hepatology · Jan 1, 2026Peer-reviewedNeuroscience