Single-Cell Epigenomics Uncovers Heterochromatin Instability and Transcription Factor Dysfunction during Mouse Brain Aging
Maria Luisa Amaral, Sainath Mamde, Michael Miller, Xiaomeng Hou, Jessica Arzavala, Julia K. Osteen, Nicholas D. Johnson, Elizabeth W. Smoot, Qian Yang, Emily R. Eisner, Qiurui Zeng, Cindy Tatiana Báez-Becerra, Jacqueline Olness, Joseph Colin Kern, Jonathan A. Rink, , Bing Ren
The paper uses single-cell epigenomics to study brain aging in mice, finding heterochromatin instability and transcription factor dysfunction across multiple brain regions and cell types.
Cell Reports · Mar 1, 2026Peer-reviewedGenomics