An optimized approach for multiplexing single-nuclear ATAC-seq using oligonucleotide conjugated antibodies
Betelehem Solomon Bera, Taylor V. Thompson, Eric Sosa, Hiroko Nomaru, David M. Reynolds, Robert A. Dubin, Shahina Bano Maqbool, Deyou Zheng, Bernice E. Morrow, John M. Greally, Masako Suzuki
The paper develops NuHash, a method for multiplexing snATAC-seq using oligonucleotide-conjugated antibodies, achieving high demultiplexing accuracy with human and mouse samples.
bioRxiv · Dec 22, 2022 · PreprintGenomics