Author

Hongyang Guo

Center for Life SciencesPrimary ORCID profile (0000-0002-7089-5298 · 1 paper)Unclaimed ORCID profile · follow to get notified of new preprints

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Hongyang GuoiD1 paper · Center for Life Sciences

Biology Disciplines

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Biochemistry· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell-cell communication· 2 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:cell type annotation· 1 Assay:imaging· 1 Research Focus:protein design· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

Wei QiniD· 2 shared Zhaofa WuiD· 2 shared Boyi CheniD· 1 shared Chun Li· 1 shared Haodong GuoiD· 1 shared Lei LüiD· 1 shared Ling ChuiD· 1 shared Liwan ZhangiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersBiochemistry

Wei QinORCID

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2 papers

Recent·Most cited

In vivo-compatible spatial multi-omics via hydrogen peroxide-independent APEX2 labeling

Boyi Chen, Hongyang Guo, Zhijian Yan, Wenjie Lu, Chun Li, Shuai Xu, Yanling Zhang, Haodong Guo, Shaopeng Sun, Xuege Sun, Shangxun Zhao, Qiaoling Shangguan, Yidong Chen, Lei Lü, Zhaofa Wu, , Wei Qin

This paper introduces Hi-APEX, a H2O2-independent APEX2 variant for in vivo spatial multi-omics, showing improved performance in capturing redox-sensitive processes and enabling in vivo applications.

Nature Chemical Biology · Oct 29, 2026Peer-reviewedBiochemistry

Silicon-rhodamine-enabled Identification (SeeID) for Near-Infrared Light Controlled Proximity Labeling In Vitro and In Vivo

Wenjing Wang, Hongyang Guo, Xiaosa Yan, Xuanzhen Pan, Xiaofei Wang, Yiming Rong, Zexiao Bai, Liwan Zhang, Zhaofa Wu, Xinyu Zhao, Weiren Huang, Wei Qin, Ling Chu

This paper introduces SeeID, a near-infrared light-controlled proximity labeling method for studying dynamic protein interactomes in vitro and in vivo, revealing proteasome association with Parkin during mitophagy.

Nature Communications · Aug 30, 2025Peer-reviewedMolecular Biology