Targeting USP2 induces degradation of PML-RARα with or without drug-resistant mutations in acute promyelocytic leukemia
Jie Zhang, Wenxuan Wu, Yun Wang, Youping Zhang, Yingying Wang, Wenhui Bai, Zhenge Zhang, Chujiao Zhu, Yunzhao Wu, Ziwei Zhang, Li Yang, Hu Lei, Hanzhang Xu, Li Zhou, Yingli Wu
This study shows that inhibiting USP2 reduces PML-RAR protein levels in APL cells, including those with drug-resistant mutations, and induces apoptosis.
Acta Biochimica et Biophysica Sinica · Jul 28, 2025Peer-reviewedCell Biology