Li Yang

Cell surface proteomics of patient-derived malignant rhabdoid tumor organoids identifies ROBO1 as potential CAR T cell target for pediatric solid tumors.

Pediatric brain charts reveal ADHD biotypes with distinct developmental, molecular, and therapeutic profiles

The paper identifies two distinct ADHD biotypes using brain imaging and transcriptomic data, showing different developmental, molecular, and treatment responses.

Molecular anatomy of the glomerular filtration barrier reveals topology-encoded albumin sieving

The paper uses cryo-ET and transport modeling to show that the glomerular basement membrane's void-network topology restricts albumin passage, explaining selectivity in the filtration barrier.

Charting sex divergence in the human brain across the lifespan

This paper constructs sex-specific lifespan brain charts using neuroimaging data from 59,915 individuals, revealing dynamic sex differences in brain development and improving detection of neuropsychiatric abnormalities.

A Dual-Pathway Wnt-IL-13 Fusion Protein Enhances Human Intestinal Regeneration Through Tuft Cell Activation

This paper develops a Wnt-IL-13 fusion protein that activates tuft cells to enhance intestinal regeneration in human organoids.

How Rare is Rare? TNFAIP3 Variants and the High Collective Burden of Haploinsufficiency

The paper identifies common hypomorphic TNFAIP3 variants associated with immune dysregulation and underdiagnosed haploinsufficiency diseases, suggesting widespread underrecognition of these conditions.

Fucoidan-Copper Nanoparticles to Potentiate Synergistic Cancer Cell Cuproptosis and Immunotherapy

This study develops fucoidan-copper nanoparticles that induce cuproptosis and enhance antitumor immunity in liver cancer cells.

Targeting USP2 induces degradation of PML-RARα with or without drug-resistant mutations in acute promyelocytic leukemia

This study shows that inhibiting USP2 reduces PML-RAR protein levels in APL cells, including those with drug-resistant mutations, and induces apoptosis.

Versatile Stain Transfer in Histopathology Using a Unified Diffusion Framework

This paper introduces DUST, a diffusion model for histopathology stain transfer, showing improved performance over GAN-based methods on a kidney histopathological dataset.

EVfold.org: Evolutionary Couplings and Protein 3D Structure Prediction

EVfold.org uses evolutionary couplings to predict protein 3D structures from sequence data with high accuracy.