Author

Hua Chen

Chinese PLA General Hospital

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Same name, identified by ORCID

Biology Disciplines

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Cancer Biology· 1 Evolutionary Biology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Adam Kinnaird· 1 shared Alois HaromyiD· 1 shared Bin Cai· 1 shared Dania Rimawi· 1 shared Evangelos D. MichelakisiD· 1 shared Gopinath SutendraiD· 1 shared Guocheng Huang· 1 shared Hong ZengiD· 1 shared

Activity by Year

2015-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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1 shared paperCancer Biology

Adam Kinnaird

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Pharmacologic Targeting of ZNF281 Suppresses Metastatic Prostate Cancer Beyond Androgen Receptor Dependence

Guocheng Huang, Maria Areli Lorenzana Carrillo, Hua Chen, Runtai Chen, Saba Abbasi Dezfouli, Joseph Nanoa, Dania Rimawi, Alois Haromy, Yuanyuan Zhao, Rohan Mittal, John Lewis, John R. Ussher, Evangelos D. Michelakis, Ronald Moore, Seyed Amirhossein Tabatabaei Dakhili, , Adam Kinnaird

This study identifies ZNF281 as a driver of metastatic prostate cancer and shows that targeting it with a novel inhibitor suppresses tumor growth and metastasis in multiple models.

bioRxiv · Sep 7, 2026 · PreprintCancer Biology

Lesion-Level-Dependent Neuroendocrine Surge Precedes Neuroinflammation and Endoplasmic Reticulum Stress in the Hypothalamus After Spinal Cord Injury: Dual-Cohort Transcriptomic Evidence for a Temporally Ordered AVP Cascade

Lianhua Li, Hong Zeng, Ming Li, Jie Gao, Hua Chen, Bin Cai, Zhi Liu

This study identifies a temporally ordered hypothalamic cascade after spinal cord injury, showing an early AVP surge precedes neuroinflammation and ER stress, with transcriptomic evidence from two rat cohorts.

bioRxiv · Apr 22, 2026 · PreprintNeuroscience

A Hidden Markov Model for Investigating Recent Positive Selection through Haplotype Structure

Hua Chen, Jody Hey, Montgomery Slatkin

This paper introduces a hidden Markov model to detect recent positive selection by analyzing haplotype structures and applies it to genomic data to estimate selection coefficients and allele ages.

Theoretical Population Biology · Feb 1, 2015Peer-reviewedEvolutionary Biology