Ming Li

Sex-stratified immune patterns across the canine lifespan and short-term responses to geroprotective interventions

This study examines age-related immune changes and short-term responses to geroprotective interventions in dogs, finding sex-stratified cytokine patterns and varied intervention effects.

Gap-free telomere-to-telomere haplotypes assembly of the hybrid grouper 'Yushuban' (Cromileptes altivelis female x Epinephelus fuscoguttatus male)

The paper presents gap-free telomere-to-telomere haplotype assemblies for a hybrid grouper, enabling genetic analysis and breeding applications.

Integrating structural and biological evidence to rerank ESMFold2 protein-protein interactions

The paper develops a framework to rerank protein-protein interactions using structural and biological evidence, improving prediction accuracy over structural-only methods.

Shared ligand-blocking mechanism but distinct conformational modulation by α5-targeting antibodies BIIG2 and MINT1526A

This study compares two anti-α5β1 antibodies, showing they share ligand-blocking mechanisms but differ in conformational modulation, with implications for therapeutic design.

Defining the genetic landscape of acid and oxidative stress tolerance in Streptococcus mutans by pooled CRISPR interference screening

This study identifies genes critical for acid and oxidative stress tolerance in Streptococcus mutans using CRISPRi screens and reveals core physiological processes involved in stress adaptation.

Medin-Induced Pro-inflammatory and Prothrombotic Activation of Coronary Artery Endothelial Cells: A Potential Novel Mediator Linking Aging and Atherosclerosis

This study shows medin induces pro-inflammatory and prothrombotic changes in endothelial cells and is strongly associated with coronary plaque burden and inflammation.

Hierarchical latent representations reveal protein organization for functional discovery and design

This paper develops a hierarchical sequence-based framework to infer distributed protein organization, identifies novel ciliary proteins, and enables synthetic protein design.

Protein structure-informed deep learning enables species-specific codon optimization

PISCO improves codon optimization by integrating protein structure and host-specific codon usage, enhancing solubility and expression.

Lesion-Level-Dependent Neuroendocrine Surge Precedes Neuroinflammation and Endoplasmic Reticulum Stress in the Hypothalamus After Spinal Cord Injury: Dual-Cohort Transcriptomic Evidence for a Temporally Ordered AVP Cascade

This study identifies a temporally ordered hypothalamic cascade after spinal cord injury, showing an early AVP surge precedes neuroinflammation and ER stress, with transcriptomic evidence from two rat cohorts.

Bacillus velezensis-derived muropeptide promotes growth of zebrafish via NOD2-mediated induction of IGF1 signaling

This study shows that a muropeptide from Bacillus velezensis promotes zebrafish growth through NOD2-mediated IGF1 signaling.

A transcriptional regulator gene TRG1 of Trichoderma longibrachiatum is involved in the regulation of peptaibols synthesis

This study identifies TRG1 as a key transcriptional regulator essential for peptaibol biosynthesis in Trichoderma longibrachiatum, showing reduced peptaibol production in a gene knockout mutant.

Physiological Reconstitution of Microtubule Doublets

This study identifies FAP53 as a key factor in B-tubule assembly during microtubule doublet formation and shows its role in ciliogenesis across species.

Modeling Thoracic Aortic Dissection Using Patient-Specific iPSCs Reveals VSMC Dysfunction and Extracellular Matrix Dysregulation

This study uses patient-specific iPSCs to model thoracic aortic dissection, revealing VSMC dysfunction and extracellular matrix dysregulation linked to COL4A2 mutations and TGF-β signaling.