Indole-3-propionic acid nano-prodrugs sustain increased lymphoid exposure and alleviate experimental autoimmune arthritis
Yitong Guo, Huiqi Wang, Brad Cleveland, Ho Yeung Leung, Dinh Chuong Nguyen, Jack Thomson Smith, J. Emiliano Gomez Medellin, Giulia Elayna Stewart, Raul Johnson, Lindsey M. Williams, Xiaoxing Wang, Peng Qiu, Tomas Mustelin, Shijie Cao
This study develops and tests nano-prodrugs of indole-3-propionic acid (IPA) to treat experimental autoimmune arthritis, showing improved lymphoid exposure and immunomodulatory effects.
bioRxiv · Oct 16, 2026 · PreprintBioengineering