The developmental stage of the medulloblastoma cell-of-origin restricts Hedgehog pathway usage and drug sensitivity
M. J. Smit, I. Armandari, I. Bockaj, T. E. I. Martini, W. W. Zomerman, Z. Siragna, T. G. J. Meeuwsen-de Boer, F. J. G. Scherpen, M. H. Schoots, M. Ritsema, W. F. A. den Dunnen, E. H. Hoving, J. T. M. L. Paridaen, G. de Haan, V. Guryev, S. Bruggeman
The paper shows that the developmental stage of medulloblastoma cell-of-origin affects Hedgehog pathway usage and drug sensitivity, with downstream pathway targets being more effective in infant patients.
bioRxiv · Jan 22, 2021Cancer Biology