Tumor-Specific CD8+ T Cells from the Bone Marrow Resist Exhaustion and Exhibit Increased Persistence in Tumor-Bearing Hosts as Compared to Tumor Infiltrating Lymphocytes
E. M. Zawidzka, L. Biavati, A. Thomas, C. L. Zanettini, L. Marchionni, R. Leone, I. Borrello
This study compares tumor-specific CD8+ T cells from the bone marrow with tumor-infiltrating lymphocytes, finding BM T cells to be more effective in persistence and function for adoptive cell therapy.
bioRxiv · Aug 28, 2023Immunology