Correlating the differences in the receptor binding domain of SARS-CoV-2 spike variants on their interactions with human ACE2 receptor
G. Mahalingam, P. Arjunan, Y. Periasami, A. K. Dhyani, N. Devaraju, V. Rajendiran, A. C. Christopher, R. D. KT, I. Darasingh, S. Thangavel, M. Murugesan, M. Moorthy, A. Srivastava, S. Marepally
The paper evaluates binding interactions of SARS-CoV-2 spike variants with hACE2 using ELISA and cellular models, finding that N501Y in RBD enhances binding efficiency, particularly distinguishing C.1.2 from Delta.
bioRxiv · Sep 30, 2022 · PreprintPharmacology & Toxicology