PAK4 regulates stemness and progression in endocrine resistant ER-positive metastatic breast cancer
A. Santiago-Gomez, I. Dragoni, R. NicAmhlaoibh, E. Trivier, V. Sabin, B. M. Simoes, J. M. Gee, A. H. Sims, S. J. Howell, R. B. Clarke
This study shows PAK4 promotes stemness and progression in ER+ metastatic breast cancer and that targeting PAK4 reverses endocrine resistance.
bioRxiv · Feb 26, 2019Cancer Biology