Optimization of pyrazolopyrimidines lead to the identification of a highly selective casein kinase 2 inhibitor
A. Kraemer, C. G. Kurz, B.-T. Berger, I. E. Celik, S. Knapp, T. Hanke
This paper describes the optimization of pyrazolopyrimidine compounds to develop a highly selective and potent CK2 inhibitor, IC20, with high in vitro potency and exclusive selectivity.
bioRxiv · Jun 27, 2020Biochemistry