Macrophages tune responses to pathogen dynamics through TLR4 stimulation memory and by licensing susceptibility to IL-10
H. Bongartz, C. T. Boughter, B. Marrero, T. Prustel, C. J. Bradfield, J. L. Gross, R. A. Gottschalk, A. Nita-Lazar, I. Fraser, M. Meier-Schellersheim
The paper shows macrophages use TLR4 memory and IL-10 susceptibility gating to adjust inflammation based on pathogen dynamics.
bioRxiv · Mar 28, 2024 · PreprintImmunology