C. T. Boughter

The paper introduces AIMS, a software tool for integrated analysis of immune repertoire data, enabling comparison across TCR, MHC, peptide, antibody, and antigen sequences to identify interaction hotspots.

The paper analyzes all possible germline-encoded TCR-MHC contacts in humans, showing that conserved interactions are rare and that biophysical compatibility, not sequence conservation, defines binding orientation.

This study modifies MR1 ligands to assess their impact on MR1-restricted T cell activation, revealing variable IFN-gamma responses and structural dynamics influencing recognition.

The paper identifies biochemical determinants of antibody polyreactivity using a bioinformatics pipeline and develops a classifier with over 75% accuracy.