G3BP1 tethers the TSC complex to lysosomes and suppresses mTORC1 in the absence of stress granules
M. T. Prentzell, U. Rehbein, M. Cadena Sandoval, A.-S. De Meulemeester, R. Baumeister, L. Brohee, B. Berdel, M. Bockwoldt, B. Carroll, A. von Deimling, C. Demetriades, G. Figlia, A. M. Heberle, I. Heiland, B. Holzwarth, , K. Thedieck
This paper shows G3BP1 anchors the TSC complex to lysosomes to suppress mTORC1 signaling without stress granules, and inhibits mTORC1-driven cancer and neuronal issues.
bioRxiv · Apr 16, 2020Cell Biology