Cell BiologybioRxiv
G3BP1 tethers the TSC complex to lysosomes and suppresses mTORC1 in the absence of stress granules
M. T. Prentzell, U. Rehbein, M. Cadena Sandoval…·K. Thedieck
This paper shows G3BP1 anchors the TSC complex to lysosomes to suppress mTORC1 signaling without stress granules, and inhibits mTORC1-driven cancer and neuronal issues.
DOI 10.1016/j.cell.2020.12.024