Distinctive desmoplastic 3D morphology associated with BRAFV600E in papillary thyroid cancers
M. Tarabichi, A. Antoniou, S. Le Pennec, D. Gacquer, N. de Saint Aubain, L. Craciun, T. Cielen, I. Laios, D. Larsimont, G. Andry, J. E. Dumont, C. Maenhaut, V. Detours
The paper describes a distinctive 3D morphology in BRAFV600E-mutated papillary thyroid cancers where tumor cells form a sparse mesh within a proliferative stroma, challenging traditional tumor growth models.
bioRxiv · Jul 6, 2017Cancer Biology