Structural basis for the mechanism and antagonism of receptor signaling mediated by Interleukin-9 (IL-9)
T. De Vos, M. Godar, F. Bick, A. Papageorgiou, T. Evangelidis, I. Markovic, E. Mortier, L. Dumoutier, K. Tripsianes, C. Blanchetot, S. N. Savvides
This study reveals the structural basis of IL-9 signaling and antagonism through crystallography and NMR, showing how IL-9 binds its receptor and how antibodies block its activity.
bioRxiv · Dec 30, 2022 · PreprintImmunology