S. N. Savvides

This study identifies AGR2 as a chaperone that regulates IRE1β activity in goblet cells by preventing its dimerization and endonuclease activity.

This study reveals the structural basis of IL-9 signaling and antagonism through crystallography and NMR, showing how IL-9 binds its receptor and how antibodies block its activity.

The paper identifies two new subunits, AmoY and AmoZ, in the ammonia monooxygenase of ammonia oxidizing archaea, revealing structural and functional complexity.

This paper determines the crystal structure of the human IL-18:IL-18BP complex, revealing the molecular mechanism of IL-18 sequestration and identifying a higher-order 2:2 assembly with enhanced activity restraint.

This paper introduces CRISPR-SID, a method to identify tumor dependencies in Xenopus models, revealing EZH2 as a druggable target for desmoid tumors.

The paper determines the structural architecture of the plant TSET complex and identifies key interactions essential for its assembly and function in endocytosis.

This study identifies distinct lipid and protein binding roles of EH domains in the TPLATE complex, revealing their functional contributions to plant clathrin-mediated endocytosis.

This study characterizes the GspLM complex of the T2SS as a dimer of dimers that binds the ATPase GspE with high affinity, suggesting its role in T2SS biogenesis.

This study shows that mutations in ATL3 cause aberrant ER membrane tethering, disrupting ER network organization and contributing to sensory neuropathy.