Author

I. Strohkendl

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:chromatin & epigenetic regulation· 1 Assay:DNA methylation· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1 Assay:structural biology· 1

Frequent Co-Authors

R. Russell· 2 shared A.-H. Nguyen· 1 shared B. A. Gibson· 1 shared C. Moy· 1 shared D. W. Taylor· 1 shared F. A. Saifuddin· 1 shared I. J. Finkelstein· 1 shared M. K. Rosen· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

8 top collaborators · 16 mutual co-author links

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2 shared papersBiochemistry

R. Russell

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2 papers

Recent·Most cited

Structural basis of Cas12a R-loop propagation on pathway to DNA cleavage

I. Strohkendl, C. Moy, A.-H. Nguyen, R. Russell, D. W. Taylor

This study uses cryo-EM to capture Cas12a R-loop intermediates, revealing how the enzyme accommodates R-loop extension and coordinates nuclease activation.

bioRxiv · Mar 13, 2023 · PreprintBiochemistry

Inhibition of CRISPR-Cas12a DNA Targeting by Nucleosomes and Chromatin

I. Strohkendl, F. A. Saifuddin, B. A. Gibson, M. K. Rosen, R. Russell, I. J. Finkelstein

This study shows that nucleosomes inhibit CRISPR-Cas12a binding and cleavage, with DNA unwrapping enhancing accessibility and cleavage rates.

bioRxiv · Jul 18, 2020Biochemistry