M. K. Rosen

This study identifies molecular features of BRD4-NUT and its interaction with p300 that drive condensate formation and gene expression, showing overlapping yet distinct roles of p300 domains.

This study shows that protein condensates and lipid domains couple to organize T-cell membrane function during activation.

The paper quantifies small molecule partitioning into biomolecular condensates and develops a machine learning model to predict partitioning based on physicochemical properties.

This study reconstitutes yeast RNA processing bodies from purified components, showing that their composition and dynamics can be recapitulated quantitatively.

This study shows that p130Cas and FAK undergo phase separation, promoting integrin clustering and IAC formation through synergistic interactions.

This study shows that intrinsic chromatin condensates exhibit liquid-like properties under diverse conditions, challenging previous claims of their solidity.

This study investigates how poly-glutamine sequences in the androgen receptor (AR) N-terminal domain influence its activity and interactions with KDM4A, suggesting a role for phase separation in regulating AR function in prostate cancer.

This study shows that global histone deacetylation during mitosis induces a chromatin phase transition that protects chromosomes from microtubule perforation and ensures proper segregation.

This study investigates how the sigma-1 receptor (S1R) forms cholesterol-enriched microdomains in the ER and modulates signaling through changes in membrane thickness and cholesterol concentration.

This study shows that phase separation can enhance enzyme activity through both concentration effects and molecular organization in synthetic condensates.

This study shows that nucleosomes inhibit CRISPR-Cas12a binding and cleavage, with DNA unwrapping enhancing accessibility and cleavage rates.

The paper studies client recruitment in biomolecular condensates using poly-SUMO and poly-SIM proteins, finding that filament structure influences functional client binding.

The paper quantifies yeast P body protein concentrations, finding only 7 proteins are highly concentrated, while others are lower, and shows sequence elements drive Dcp2 localization.

This study identifies a noncanonical role for dynamin in cell-cell fusion by directly bundling actin filaments through GTPase-dependent interactions.

This study shows phosphorylated Nephrin forms phase-separated domains at the plasma membrane, which move via actomyosin contraction.

This study shows that chromatin undergoes liquid-liquid phase separation under physiological conditions, driven by histone tail interactions and modulated by acetylation and H1, leading to genome compaction and organization.

The paper investigates how Nck and WASP mediate the movement of LAT condensates across actin networks during T cell activation.

This study shows that disordered linkers in multivalent proteins control the relationship between phase separation and gelation through their length and sequence features.

The paper shows that intrinsically disordered regions contribute promiscuous interactions to RNP granule assembly, working with specific interactions to form large cellular structures.