Tuning of granulopoietic signaling by de novo designed agonists
T. Ullrich, C. Pollmann, M. Ritter, J. Haaf, N. Aghaallaei, I. Tesakov, M. El-Riz, K. Maksymenko, V. Hatskovska, S. Kandabarau, M. Klimiankou, C. Lengerke, K. Welte, B. Hernandez Alvarez, P. Müller, , M. ElGamacy
This paper designs and characterizes agonists that tune G-CSFR activity to bias granulopoiesis over proliferation, showing improved stability and selectivity compared to native G-CSF.
bioRxiv · Nov 25, 2023 · PreprintBioengineering