Locus-specific spatial and transcriptional dynamics direct T cell lineage choice in the thymus
Ilinca Patrascan, James W. D. King, Noura Maziak, Rebecca Marie Crossley, Samuel Johnson, Arianna Ceccarelli, Ian McFarlane, Ya Guo, Mohammad Mahdi Karimi, Amanda G. Fisher, Ruth E. Baker, Juan M. Vaquerizas, Matthias Merkenschlager
The paper investigates how spatial and transcriptional dynamics at Cd4 and Cd8 loci influence T cell lineage choice in the thymus, revealing locus-specific chromatin environments that drive differentiation.
bioRxiv · Oct 27, 2026 · PreprintGenetics