Precursor of chemically expanded hepatocytes (pre-cHep) with 1-million-fold expansion potential and liver repopulation capacity
Linh Huynh, Yuichiro Higuchi, Cherie Tsz‐Yiu Law, Jakob Jeriha, Ines Battle, Rebecca Granskog, Shotaro Uehara, Fumihiko Kawamura, Victoria L. Gadd, Tak Yung Man, Stuart John Forbes, Kosuke Yusa, Stephen Kwok‐Wing Tsui, Hiroshi Suemizu, Keisuke Kaji
The paper reports a method to reprogram primary human hepatocytes into proliferative pre-cHep cells with high expansion potential and liver repopulation capacity, offering an alternative to PHHs for drug testing and disease modeling.
bioRxiv · May 19, 2026 · PreprintBioengineering